Raspberry ketone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

4-(4-羟基苯基)-2-丁酮 (RK) 通过 RK 衍生醌与硫醇蛋白的结合以及 RK 低聚物的促氧化活性对黑素细胞产生细胞毒性。

4-(4-Hydroxyphenyl)-2-butanone(RK) is cytotoxic to melanocytes through the binding of RK-derived quinones to thiol proteins and the pro-oxidant activity of the RK-oligomer, the exposure of human skin to RK can cause chemical/occupational leukoderma. 4-(4-Hydroxyphenyl)-2-butanone is marketed on the Internet as a food supplement.

Raspberry ketone (1, 10, 20, and 50?μM) suppresses adipogenesis and lipid accumulation in 3T3-L1 pre-adipocytes. Raspberry ketone (10?μM) significantly blocks C/EBPα, PPARγ, and aP2 expression and increases the expression of ATGL and HSL, and CPT1B.

Raspberry ketone (0.5%, 1%, or 2%) increasses the levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol contents (LDL-C), ISI (insulin-sensitivr index), PPAR-α and LDLR, decreases the serum levels of AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), IRI (insulin resistance index), GLU (glucose), INS (insulin-sensitivr index), LEP (leptin), and TNF-α in rats compared with a high-fat diet-induced NASH model. Raspberry ketone also causes increased SOD activities. Raspberry ketone shows cardioprotective action against isoproterenol-induced myocardial infarction in rats, and the effects may be due to its PPAR-α agonistic activity.

Frambione | 4-(4-Hydroxyphenyl)-2-butanone

Cytoskeleton/Cell Adhesion Molecules

Microtubule/Tubulin

Others

Others-Field

——

5471-51-2

164.2

C10H12O2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (609.01 mM)

CC(=O)CCC1=CC=C(C=C1)O

——

(-20℃)

With Ice Pack

≥ 2 years